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Two-stage optimal designs based on exact variance for a single-arm trial with survival endpoints

Sample size calculation based on normal approximations is often associated with the loss of statistical power for a single-arm trial with time-to-event endpoint. Recently, Wu (2015) derived the exact variance for the one-sample log-rank test under the alternative, and showed that a single-arm one-st...

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Pubblicato in:J Biopharm Stat
Autore principale: Shan, Guogen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415526/
https://ncbi.nlm.nih.gov/pubmed/32129130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2020.1730869
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