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Extended Two-stage Adaptive Designs with Three Target Responses for Phase II Clinical Trials
We develop a nature-inspired stochastic population-based algorithm and call it discrete particle swarm optimization (DPSO) to find extended two-stage adaptive optimal designs that allow 3 target response rates for the drug in a phase II trial. Our proposed designs include the celebrated Simon’s two-...
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| Publicado no: | Stat Methods Med Res |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5515697/ https://ncbi.nlm.nih.gov/pubmed/28535716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0962280217709817 |
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