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Phase II Two-Stage Single-Arm Clinical Trials for Testing Toxicity Levels

Simon’s two-stage designs are frequently used in phase II single-arm trials for efficacy studies. In safety studies, a main concern is that there may be too many patients who experience an adverse event. We show that Simon’s two-stage designs for efficacy studies can be similarly used to design a tw...

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Detalhes bibliográficos
Publicado no:Commun Stat Appl Methods
Main Authors: Kim, Seongho, Wong, Weng Kee
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522135/
https://ncbi.nlm.nih.gov/pubmed/31106162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.29220/CSAM.2019.26.2.163
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