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Statistical inference for extended or shortened phase II studies based on Simon’s two-stage designs

BACKGROUND: Simon’s two-stage designs are popular choices for conducting phase II clinical trials, especially in the oncology trials to reduce the number of patients placed on ineffective experimental therapies. Recently Koyama and Chen (2008) discussed how to conduct proper inference for such studi...

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Detalhes bibliográficos
Publicado no:BMC Med Res Methodol
Main Authors: Zhao, Junjun, Yu, Menggang, Feng, Xi-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535394/
https://ncbi.nlm.nih.gov/pubmed/26048655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-015-0039-5
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