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Proper inference from Simon’s two-stage designs

Simon’s two-stage designs are very popular for phase II clinical trials. A literature review revealed that the inference procedures used with Simon’s designs almost always ignore the actual sampling plan used. Reported P values, point estimates and confidence intervals for the response rate are not...

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Dettagli Bibliografici
Pubblicato in:Stat Med
Autori principali: Koyama, Tatsuki, Chen, Heidi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047527/
https://ncbi.nlm.nih.gov/pubmed/17960777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3123
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