RARα2 and PML-RAR similarities in the control of basal and retinoic acid induced myeloid maturation of acute myeloid leukemia cells

Treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) is the first example of targeted therapy. In fact, the oncogenic fusion-protein (PML-RAR) typical of this leukemia contains the retinoid-nuclear-receptor RARα. PML-RAR is responsible for the differentiation block of...

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Udgivet i:Oncotarget
Main Authors: Gianni, Maurizio, Fratelli, Maddalena, Bolis, Marco, Kurosaki, Mami, Zanetti, Adriana, Paroni, Gabriela, Rambaldi, Alessandro, Borleri, Gianmaria, Rochette-Egly, Cecile, Terao, Mineko, Garattini, Enrico
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514891/
https://ncbi.nlm.nih.gov/pubmed/27419624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10556
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