Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives

In an effort to discover potent camptothecin-derived antitumor agents, novel camptothecin analogues with sulfonylpiperazinyl motifs at position-7 were designed and synthesized. They were evaluated for in vitro cytotoxicity with the sulforhodamine-B (SRB) method in five types of human tumor cell line...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Zhu, Gao-Xiang, Cheng, Pi-Le, Goto, Masuo, Zhang, Na, Morris-Natschke, Susan L., Hsieh, Kan-Yen, Yang, Guan-Zhou, Yang, Qian-Ru, Liu, Ying-Qian, Chen, Hai-Le, Zhang, Xiao-Shuai, Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512430/
https://ncbi.nlm.nih.gov/pubmed/28285912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.02.066
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