Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives

Fluorination is a well-known strategy for improving the bioavailability of bioactive molecules in the lead optimization phase of drug discovery projects. In an attempt to improve the antitumor activity of camptothecins (CPTs), novel 10-fluoro-CPT derivatives were designed, synthesized and evaluated...

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Publicado en:Bioorg Med Chem Lett
Autores principales: Yang, Cheng-Jie, Song, Zi-Long, Goto, Masuo, Hsu, Pei-Ling, Zhang, Xiao-Shuai, Yang, Qian-Ru, Liu, Ying-Qian, Wang, Mei-Juan, Morris-Natschke, Susan L., Shang, Xiao-Fei, Lee, Kuo-Hsiung
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831374/
https://ncbi.nlm.nih.gov/pubmed/28927790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.09.012
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