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Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives
Fluorination is a well-known strategy for improving the bioavailability of bioactive molecules in the lead optimization phase of drug discovery projects. In an attempt to improve the antitumor activity of camptothecins (CPTs), novel 10-fluoro-CPT derivatives were designed, synthesized and evaluated...
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| Publicado no: | Bioorg Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5831374/ https://ncbi.nlm.nih.gov/pubmed/28927790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.09.012 |
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