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Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca(2+)-sensitizing mutations

Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in response to Ca(2+). TnC binding Ca(2+) initiates a cascade of protein–protein interactions that begins with the opening of the N-terminal domain of cTnC, followed by cTnC binding the troponin I switch peptide (...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Stevens, Charles M., Rayani, Kaveh, Singh, Gurpreet, Lotfalisalmasi, Bairam, Tieleman, D. Peter, Tibbits, Glen F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512083/
https://ncbi.nlm.nih.gov/pubmed/28533433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770776
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