Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC

Zebrafish, as a model for teleost fish, have two paralogous troponin C (TnC) genes that are expressed in the heart differentially in response to temperature acclimation. Upon Ca(2+) binding, TnC changes conformation and exposes a hydrophobic patch that interacts with troponin I and initiates cardiac...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Stevens, Charles M., Rayani, Kaveh, Genge, Christine E., Singh, Gurpreet, Liang, Bo, Roller, Janine M., Li, Cindy, Li, Alison Yueh, Tieleman, D. Peter, van Petegem, Filip, Tibbits, Glen F.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2016
Assuntos:
Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944662/
https://ncbi.nlm.nih.gov/pubmed/27410732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.05.029
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