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Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca(2+)-sensitizing mutations
Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in response to Ca(2+). TnC binding Ca(2+) initiates a cascade of protein–protein interactions that begins with the opening of the N-terminal domain of cTnC, followed by cTnC binding the troponin I switch peptide (...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5512083/ https://ncbi.nlm.nih.gov/pubmed/28533433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770776 |
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