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Familial Hypertrophic Cardiomyopathy Related Cardiac Troponin C L29Q Mutation Alters Length-Dependent Activation and Functional Effects of Phosphomimetic Troponin I*

The Ca(2+) binding properties of the FHC-associated cardiac troponin C (cTnC) mutation L29Q were examined in isolated cTnC, troponin complexes, reconstituted thin filament preparations, and skinned cardiomyocytes. While higher Ca(2+) binding affinity was apparent for the L29Q mutant in isolated cTnC...

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Главные авторы: Li, Alison Y., Stevens, Charles M., Liang, Bo, Rayani, Kaveh, Little, Sean, Davis, Jonathan, Tibbits, Glen F.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832503/
https://ncbi.nlm.nih.gov/pubmed/24260207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079363
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