Measurement of Calcium Dissociation Rates from Troponin C in Rigor Skeletal Myofibrils

Por Little, Sean C., Tikunova, Svetlana B., Norman, Catalina, Swartz, Darl R., Davis, Jonathan P.
Publicado em 2011

Familial Hypertrophic Cardiomyopathy Related Cardiac Troponin C L29Q Mutation Alters Length-Dependent Activation and Functional Effects of Phosphomimetic Troponin I*

Por Li, Alison Y., Stevens, Charles M., Liang, Bo, Rayani, Kaveh, Little, Sean, Davis, Jonathan, Tibbits, Glen F.
Publicado em 2013

The Rates of Ca(2+) Dissociation and Cross-bridge Detachment from Ventricular Myofibrils as Reported by a Fluorescent Cardiac Troponin C

Por Little, Sean C., Biesiadecki, Brandon J., Kilic, Ahmet, Higgins, Robert S. D., Janssen, Paul M. L., Davis, Jonathan P.
Publicado em 2012

Effect of Calcium-sensitizing Mutations on Calcium Binding and Exchange with Troponin C in Increasingly Complex Biochemical Systems

Por Tikunova, Svetlana B., Liu, Bin, Swindle, Nicholas, Little, Sean C., Gomes, Aldrin V., Swartz, Darl R., Davis, Jonathan P.
Publicado em 2010

AMP-activated Protein Kinase Phosphorylates Cardiac Troponin I at Ser-150 to Increase Myofilament Calcium Sensitivity and Blunt PKA-dependent Function

Por Nixon, Benjamin R., Thawornkaiwong, Ariyoporn, Jin, Janel, Brundage, Elizabeth A., Little, Sean C., Davis, Jonathan P., Solaro, R. John, Biesiadecki, Brandon J.
Publicado em 2012

Combined Troponin I Ser-150 and Ser-23/24 Phosphorylation Sustains Thin Filament Ca(2+) Sensitivity and Accelerates Deactivation in an Acidic Environment()

Por Nixon, Benjamin R., Walton, Shane D., Zhang, Bo, Brundage, Elizabeth A., Little, Sean C., Ziolo, Mark T., Davis, Jonathan P., Biesiadecki, Brandon J.
Publicado em 2014

Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca(2+) Channel Targeting and Function in the Atria

Por Curran, Jerry, Musa, Hassan, Kline, Crystal F., Makara, Michael A., Little, Sean C., Higgins, John D., Hund, Thomas J., Band, Hamid, Mohler, Peter J.
Publicado no J Biol Chem (2015)

Designing Proteins to Combat Disease: Cardiac Troponin C as an Example

Por Davis, Jonathan P., Shettigar, Vikram, Tikunova, Svetlana B., Little, Sean C., Liu, Bin, Siddiqui, Jalal K., Janssen, Paul M.L., Ziolo, Mark T., Walton, Shane D.
Publicado no Arch Biochem Biophys (2016)

Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function in vivo

Por Glynn, Patric, Musa, Hassan, Wu, Xiangqiong, Unudurthi, Sathya D., Little, Sean, Qian, Lan, Wright, Patrick J., Radwanski, Przemyslaw B., Gyorke, Sandor, Mohler, Peter J., Hund, Thomas J.
Publicado no Circulation (2015)

Ankyrin-G Coordinates Intercalated Disc Signaling Platform to Regulate Cardiac Excitability In Vivo

Por Makara, Michael A., Curran, Jerry, Little, Sean C., Musa, Hassan, Polina, Iuliia, Smith, Sakima A., Wright, Patrick J., Unudurthi, Sathya D., Snyder, Jed, Bennett, Vann, Hund, Thomas J., Mohler, Peter J.
Publicado no Circ Res (2014)

Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall

Por Liu, Xiaoping, El-Mahdy, Mohamed A., Boslett, James, Varadharaj, Saradhadevi, Hemann, Craig, Abdelghany, Tamer M., Ismail, Raed S., Little, Sean C., Zhou, Danlei, Thuy, Le Thi Thanh, Kawada, Norifumi, Zweier, Jay L.
Publicado no Nat Commun (2017)

Obligatory Role of Neuronal Nitric Oxide Synthase in the Heart’s Antioxidant Adaptation with Exercise

Por Roof, Steve R, Ho, Hsiang-Ting, Little, Sean C, Ostler, Joseph E, Brundage, Elizabeth A, Periasamy, Muthu, Villamena, Frederick A, Györke, Sandor, Biesiadecki, Brandon J, Heymes, Christophe, Houser, Steven R, Davis, Jonathan P, Ziolo, Mark T
Publicado no J Mol Cell Cardiol (2015)

EHD3-Dependent Endosome Pathway Regulates Cardiac Membrane Excitability and Physiology

Por Curran, Jerry, Makara, Michael A., Little, Sean C., Musa, Hassan, Liu, Bin, Wu, Xiangqiong, Polina, Iuliia, Alecusan, Joe, Wright, Patrick, Li, Jingdong, Billman, George E., Boyden, Penelope A., Gyorke, Sandor, Band, Hamid, Hund, Thomas J., Mohler, Peter J.
Publicado em 2014

Molecular Mechanisms Underlying Cardiac Protein Phosphatase 2A Regulation in Heart

Por DeGrande, Sean T., Little, Sean C., Nixon, Derek J., Wright, Patrick, Snyder, Jedidiah, Dun, Wen, Murphy, Nathaniel, Kilic, Ahmet, Higgins, Robert, Binkley, Philip F., Boyden, Penelope A., Carnes, Cynthia A., Anderson, Mark E., Hund, Thomas J., Mohler, Peter J.
Publicado em 2013

Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure

Por Makara, Michael A., Curran, Jerry, Lubbers, Ellen R., Murphy, Nathaniel P., Little, Sean C., Musa, Hassan, Smith, Sakima A., Unudurthi, Sathya D., Rajaram, Murugesan V.S., Janssen, Paul M.L., Boyden, Penelope A., Bradley, Elisa A., Hund, Thomas J., Mohler, Peter J.
Publicado no JACC Basic Transl Sci (2018)

Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart

Por Little, Sean C., Curran, Jerry, Makara, Michael A., Kline, Crystal F., Ho, Hsiang-Ting, Xu, Zhaobin, Wu, Xiangqiong, Polina, Iuliia, Musa, Hassan, Meadows, Allison M., Carnes, Cynthia A., Biesiadecki, Brandon J., Davis, Jonathan P., Weisleder, Noah, Györke, Sandor, Wehrens, Xander H., Hund, Thomas J., Mohler, Peter J.
Publicado no Sci Signal (2015)

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

Por Shettigar, Vikram, Zhang, Bo, Little, Sean C., Salhi, Hussam E., Hansen, Brian J., Li, Ning, Zhang, Jianchao, Roof, Steve R., Ho, Hsiang-Ting, Brunello, Lucia, Lerch, Jessica K., Weisleder, Noah, Fedorov, Vadim V., Accornero, Federica, Rafael-Fortney, Jill A., Gyorke, Sandor, Janssen, Paul M. L., Biesiadecki, Brandon J., Ziolo, Mark T., Davis, Jonathan P.
Publicado no Nat Commun (2016)

NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

Por Peterson, Jennifer M., Wang, David J., Shettigar, Vikram, Roof, Steve R., Canan, Benjamin D., Bakkar, Nadine, Shintaku, Jonathan, Gu, Jin-Mo, Little, Sean C., Ratnam, Nivedita M., Londhe, Priya, Lu, Leina, Gaw, Christopher E., Petrosino, Jennifer M., Liyanarachchi, Sandya, Wang, Huating, Janssen, Paul M. L., Davis, Jonathan P., Ziolo, Mark T., Sharma, Sudarshana M., Guttridge, Denis C.
Publicado no Nat Commun (2018)

Dysfunction in the βII Spectrin-Dependent Cytoskeleton Underlies Human Arrhythmia

Por Smith, Sakima A., Sturm, Amy C., Curran, Jerry, Kline, Crystal F., Little, Sean C., Bonilla, Ingrid M., Long, Victor P., Makara, Michael, Polina, Iuliia, Hughes, Langston D., Webb, Tyler R., Wei, Zhiyi, Wright, Patrick, Voigt, Niels, Bhakta, Deepak, Spoonamore, Katherine G., Zhang, Chuansheng, Weiss, Raul, Binkley, Philip F., Janssen, Paul M., Kilic, Ahmet, Higgins, Robert S., Sun, Mingzhai, Ma, Jianjie, Dobrev, Dobromir, Zhang, Mingjie, Carnes, Cynthia A., Vatta, Matteo, Rasband, Matthew N., Hund, Thomas J., Mohler, Peter J.
Publicado no Circulation (2015)