AMP-activated Protein Kinase Phosphorylates Cardiac Troponin I at Ser-150 to Increase Myofilament Calcium Sensitivity and Blunt PKA-dependent Function

AMP-activated protein kinase (AMPK) is an energy-sensing enzyme central to the regulation of metabolic homeostasis. In the heart AMPK is activated during cardiac stress-induced ATP depletion and functions to stimulate metabolic pathways that restore the AMP/ATP balance. Recently it was demonstrated...

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Detalhes bibliográficos
Main Authors: Nixon, Benjamin R., Thawornkaiwong, Ariyoporn, Jin, Janel, Brundage, Elizabeth A., Little, Sean C., Davis, Jonathan P., Solaro, R. John, Biesiadecki, Brandon J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365946/
https://ncbi.nlm.nih.gov/pubmed/22493448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.323048
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