Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function in vivo

BACKGROUND: Voltage-gated Na(+) channels (Na(v)) are essential for myocyte membrane excitability and cardiac function. Na(v) current (I(Na)) is a large amplitude, short duration “spike” generated by rapid channel activation followed immediately by inactivation. However, even under normal conditions,...

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Pubblicato in:Circulation
Autori principali: Glynn, Patric, Musa, Hassan, Wu, Xiangqiong, Unudurthi, Sathya D., Little, Sean, Qian, Lan, Wright, Patrick J., Radwanski, Przemyslaw B., Gyorke, Sandor, Mohler, Peter J., Hund, Thomas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543581/
https://ncbi.nlm.nih.gov/pubmed/26187182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.114.015218
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