Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation

Inhibition of the microtubule (MT) motor protein Eg5 results in a mitotic arrest due to the formation of monopolar spindles, making Eg5 an attractive target for anti-cancer therapies. However, Eg5-independent pathways for bipolar spindle formation exist, which might promote resistance to treatment w...

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Bibliografiske detaljer
Udgivet i:Chromosoma
Main Authors: van Heesbeen, Roy G. H. P., Raaijmakers, Jonne A., Tanenbaum, Marvin E., Halim, Vincentius A., Lelieveld, Daphne, Lieftink, Cor, Heck, Albert J. R., Egan, David A., Medema, René H.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509784/
https://ncbi.nlm.nih.gov/pubmed/27354041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00412-016-0607-4
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