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Nuclear envelope-associated dynein cooperates with Eg5 to drive prophase centrosome separation

Eg5 (kinesin-5) is a highly conserved microtubule motor protein, essential for centrosome separation and bipolar spindle assembly in human cells. Using an “in vitro” evolution approach, we generated human cancer cells that can grow in the complete absence of Eg5 activity. Characterization of these E...

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Main Authors: van Heesbeen, Roy G.H.P., Raaijmakers, Jonne A., Tanenbaum, Marvin E., Medema, René H.
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656018/
https://ncbi.nlm.nih.gov/pubmed/23713137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cib.23841
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