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Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation
The microtubule motor protein kinesin-5 (Eg5) provides an outward force on centrosomes, which drives bipolar spindle assembly. Acute inhibition of Eg5 blocks centrosome separation and causes mitotic arrest in human cells, making Eg5 an attractive target for anti-cancer therapy. Using in vitro direct...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
European Molecular Biology Organization
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3492733/ https://ncbi.nlm.nih.gov/pubmed/23034402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.272 |
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