Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses

Determining fetal drug exposure (except at the time of birth) is not possible for both logistical and ethical reasons. Therefore, we developed a novel maternal-fetal physiologically based pharmacokinetic (m-f-PBPK) model to predict fetal exposure to drugs and populated this model with gestational ag...

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Bibliographic Details
Published in:Drug Metab Dispos
Main Authors: Zhang, Zufei, Imperial, Marjorie Z., Patilea-Vrana, Gabriela I., Wedagedera, Janak, Gaohua, Lu, Unadkat, Jashvant D.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5506457/
https://ncbi.nlm.nih.gov/pubmed/28588050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.075192
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