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Quantifying Hepatic Enzyme Kinetics of (-)-∆(9)-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC, through In Vitro Modeling
The prevalence of cannabis use and the concentrations of the psychoactive cannabinoid in cannabis, (-)-∆(9)-tetrahydrocannabinol (THC), are rising. Physiologically based pharmacokinetic modeling and simulations (PBPK M&S) can mechanistically predict exposure of THC and its major and active metab...
Gardado en:
| Publicado en: | Drug Metab Dispos |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6556521/ https://ncbi.nlm.nih.gov/pubmed/31048453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.086470 |
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