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Quantifying Hepatic Enzyme Kinetics of (-)-∆(9)-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC, through In Vitro Modeling

The prevalence of cannabis use and the concentrations of the psychoactive cannabinoid in cannabis, (-)-∆(9)-tetrahydrocannabinol (THC), are rising. Physiologically based pharmacokinetic modeling and simulations (PBPK M&S) can mechanistically predict exposure of THC and its major and active metab...

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Detaylı Bibliyografya
Yayımlandı:Drug Metab Dispos
Asıl Yazarlar: Patilea-Vrana, Gabriela I., Unadkat, Jashvant D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556521/
https://ncbi.nlm.nih.gov/pubmed/31048453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.086470
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