Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1

Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression of the endogenous peptide urocortin1 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human articular chondrocytes (AC) and demonstrate its r...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Lawrence, K. M., Jones, R. C., Jackson, T. R., Baylie, R. L., Abbott, B., Bruhn-Olszewska, B., Board, T. N., Locke, I. C., Richardson, S. M., Townsend, P. A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505992/
https://ncbi.nlm.nih.gov/pubmed/28698554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04367-4
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