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Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1
Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression of the endogenous peptide urocortin1 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human articular chondrocytes (AC) and demonstrate its r...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5505992/ https://ncbi.nlm.nih.gov/pubmed/28698554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04367-4 |
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