Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1

Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression of the endogenous peptide urocortin1 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human articular chondrocytes (AC) and demonstrate its r...

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Foilsithe in:Sci Rep
Main Authors: Lawrence, K. M., Jones, R. C., Jackson, T. R., Baylie, R. L., Abbott, B., Bruhn-Olszewska, B., Board, T. N., Locke, I. C., Richardson, S. M., Townsend, P. A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505992/
https://ncbi.nlm.nih.gov/pubmed/28698554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04367-4
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