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Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1
Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression of the endogenous peptide urocortin1 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human articular chondrocytes (AC) and demonstrate its r...
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| Vydáno v: | Sci Rep |
|---|---|
| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5505992/ https://ncbi.nlm.nih.gov/pubmed/28698554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04367-4 |
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