The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration

Neurons exhibit a limited ability of repair. Given that mechanical forces affect neuronal outgrowth, it is important to investigate whether mechanosensitive ion channels may regulate axon regeneration. Here, we show that DmPiezo, a Ca(2+)-permeable non-selective cation channel, functions as an intri...

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Gepubliceerd in:Neuron
Hoofdauteurs: Song, Yuanquan, Li, Dan, Farrelly, Olivia, Miles, Leann, Li, Feng, Kim, Sung Eun, Lo, Tsz Y., Wang, Fei, Li, Tun, Thompson-Peer, Katherine L., Gong, Jiaxin, Murthy, Swetha E., Coste, Bertrand, Yakubovich, Nikita, Patapoutian, Ardem, Xiang, Yang, Rompolas, Panteleimon, Jan, Lily Yeh, Jan, Yuh Nung
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487666/
https://ncbi.nlm.nih.gov/pubmed/30819546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.01.050
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