Endogenous Piezo1 can confound mechanically-activated channel identification and characterization

A gold standard for characterizing mechanically-activated (MA) currents is via heterologous expression of candidate channels in naïve cells. Two recent studies described MA channels using this paradigm. TMEM150c was proposed to be a component of a MA channel partly based on a heterologous expression...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Dubin, Adrienne E., Murthy, Swetha, Lewis, Amanda H., Brosse, Lucie, Cahalan, Stuart M., Grandl, Jörg, Coste, Bertrand, Patapoutian, Ardem
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448662/
https://ncbi.nlm.nih.gov/pubmed/28426961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.03.039
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