Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis

Impairment in cholesterol metabolism is associated with many neurodegenerative disorders including Alzheimer's disease (AD). However, the lipid alterations underlying neurodegeneration and the connection between altered cholesterol levels and AD remains not fully understood. We recently showed...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Ayciriex, Sophie, Djelti, Fathia, Alves, Sandro, Regazzetti, Anne, Gaudin, Mathieu, Varin, Jennifer, Langui, Dominique, Bièche, Ivan, Hudry, Eloise, Dargère, Delphine, Aubourg, Patrick, Auzeil, Nicolas, Laprévote, Olivier, Cartier, Nathalie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504187/
https://ncbi.nlm.nih.gov/pubmed/28744197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00211
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