CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

Huntington’s disease is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin (Exp-HTT) leading to degeneration of striatal neurons. Altered brain cholesterol homeostasis has been implicated in Huntington’s disease, with increased accumulation of ch...

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Bibliografische gegevens
Gepubliceerd in:Brain
Hoofdauteurs: Boussicault, Lydie, Alves, Sandro, Lamazière, Antonin, Planques, Anabelle, Heck, Nicolas, Moumné, Lara, Despres, Gaëtan, Bolte, Susanne, Hu, Amélie, Pagès, Christiane, Galvan, Laurie, Piguet, Francoise, Aubourg, Patrick, Cartier, Nathalie, Caboche, Jocelyne, Betuing, Sandrine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2016
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766376/
https://ncbi.nlm.nih.gov/pubmed/26912634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv384
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