CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

Huntington’s disease is an autosomal dominant neurodegenerative disease caused by abnormal polyglutamine expansion in huntingtin (Exp-HTT) leading to degeneration of striatal neurons. Altered brain cholesterol homeostasis has been implicated in Huntington’s disease, with increased accumulation of ch...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Brain
Главные авторы: Boussicault, Lydie, Alves, Sandro, Lamazière, Antonin, Planques, Anabelle, Heck, Nicolas, Moumné, Lara, Despres, Gaëtan, Bolte, Susanne, Hu, Amélie, Pagès, Christiane, Galvan, Laurie, Piguet, Francoise, Aubourg, Patrick, Cartier, Nathalie, Caboche, Jocelyne, Betuing, Sandrine
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766376/
https://ncbi.nlm.nih.gov/pubmed/26912634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv384
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы