Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis

Impairment in cholesterol metabolism is associated with many neurodegenerative disorders including Alzheimer's disease (AD). However, the lipid alterations underlying neurodegeneration and the connection between altered cholesterol levels and AD remains not fully understood. We recently showed...

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Vydáno v:Front Mol Neurosci
Hlavní autoři: Ayciriex, Sophie, Djelti, Fathia, Alves, Sandro, Regazzetti, Anne, Gaudin, Mathieu, Varin, Jennifer, Langui, Dominique, Bièche, Ivan, Hudry, Eloise, Dargère, Delphine, Aubourg, Patrick, Auzeil, Nicolas, Laprévote, Olivier, Cartier, Nathalie
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504187/
https://ncbi.nlm.nih.gov/pubmed/28744197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00211
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