The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma

Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of pancreatic ductal adenocarcinoma (PDAC). A hallmark of PDAC is the desmoplastic reaction, but the impact of the tumor microenvironment (TME) on CSCs is unknown. In order to better understand the mechanisms, we...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Begum, Asma, Ewachiw, Theodore, Jung, Clinton, Huang, Ally, Norberg, K. Jessica, Marchionni, Luigi, McMillan, Ross, Penchev, Vesselin, Rajeshkumar, N. V., Maitra, Anirban, Wood, Laura, Wang, Chenguang, Wolfgang, Christopher, DeJesus-Acosta, Ana, Laheru, Daniel, Shapiro, Irina M., Padval, Mahesh, Pachter, Jonathan A., Weaver, David T., Rasheed, Zeshaan A., Matsui, William
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503247/
https://ncbi.nlm.nih.gov/pubmed/28692661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180181
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