The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma

Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of pancreatic ductal adenocarcinoma (PDAC). A hallmark of PDAC is the desmoplastic reaction, but the impact of the tumor microenvironment (TME) on CSCs is unknown. In order to better understand the mechanisms, we...

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Publicado en:PLoS One
Autores principales: Begum, Asma, Ewachiw, Theodore, Jung, Clinton, Huang, Ally, Norberg, K. Jessica, Marchionni, Luigi, McMillan, Ross, Penchev, Vesselin, Rajeshkumar, N. V., Maitra, Anirban, Wood, Laura, Wang, Chenguang, Wolfgang, Christopher, DeJesus-Acosta, Ana, Laheru, Daniel, Shapiro, Irina M., Padval, Mahesh, Pachter, Jonathan A., Weaver, David T., Rasheed, Zeshaan A., Matsui, William
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503247/
https://ncbi.nlm.nih.gov/pubmed/28692661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180181
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