The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma

Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of pancreatic ductal adenocarcinoma (PDAC). A hallmark of PDAC is the desmoplastic reaction, but the impact of the tumor microenvironment (TME) on CSCs is unknown. In order to better understand the mechanisms, we...

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Publicat a:PLoS One
Autors principals: Begum, Asma, Ewachiw, Theodore, Jung, Clinton, Huang, Ally, Norberg, K. Jessica, Marchionni, Luigi, McMillan, Ross, Penchev, Vesselin, Rajeshkumar, N. V., Maitra, Anirban, Wood, Laura, Wang, Chenguang, Wolfgang, Christopher, DeJesus-Acosta, Ana, Laheru, Daniel, Shapiro, Irina M., Padval, Mahesh, Pachter, Jonathan A., Weaver, David T., Rasheed, Zeshaan A., Matsui, William
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503247/
https://ncbi.nlm.nih.gov/pubmed/28692661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180181
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