IQGAP1 Maintains Pancreatic Ductal Adenocarcinoma Clonogenic Growth and Metastasis

OBJECTIVES: IQ motif containing GTPase activating protein 1 (IQGAP1) acts as a scaffold for aberrant MAPK signaling driven by KRAS mutations in pancreatic ductal adenocarcinoma (PDAC). We determined the role of IQGAP1 in clonogenic growth and metastasis in PDAC. METHODS: We inhibited IQGAP1 expressi...

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Udgivet i:Pancreas
Main Authors: Li, Joey H., McMillan, Ross H., Begum, Asma, Gocke, Christian B., Matsui, William
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293988/
https://ncbi.nlm.nih.gov/pubmed/30540680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000001198
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