IQGAP1 Scaffold-MAP Kinase Interactions Enhance Multiple Myeloma Clonogenic Growth and Self-Renewal

Despite improved outcomes in newly diagnosed multiple myeloma (MM), virtually all patients relapse and ultimately develop drug-resistant disease. Aberrant RAS/MAPK signaling is activated in the majority of relapsed/refractory MM patients, but its biological consequences are not fully understood. Sel...

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Опубликовано в: :Mol Cancer Ther
Главные авторы: Gocke, Christian B., McMillan, Ross, Wang, Qiuju, Begum, Asma, Penchev, Vesselin, Ali, Syed A., Borrello, Ivan, Huff, Carol Ann, Matsui, William
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097000/
https://ncbi.nlm.nih.gov/pubmed/27573425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0323
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