Activation of Liver X Receptors inhibits of Hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma

The Hedgehog (Hh) signaling pathway is aberrantly activated in a wide variety of human cancers, and recent clinical studies have demonstrated that pathway inhibitors are effective in advanced basal cell carcinoma (BCC). The majority of these agents have been designed to target SMOOTHENED (SMO), a tr...

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Bibliographic Details
Main Authors: Agarwal, Jasmin R., Wang, Qiuju, Tanno, Toshihiko, Rasheed, Zeshaan, Merchant, Akil, Ghosh, Nilanjan, Borrello, Ivan, Huff, Carol Ann, Parhami, Farhad, Matsui, William
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182725/
https://ncbi.nlm.nih.gov/pubmed/24807964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0997
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