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Activation of Liver X Receptors inhibits of Hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma

The Hedgehog (Hh) signaling pathway is aberrantly activated in a wide variety of human cancers, and recent clinical studies have demonstrated that pathway inhibitors are effective in advanced basal cell carcinoma (BCC). The majority of these agents have been designed to target SMOOTHENED (SMO), a tr...

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Bibliografische gegevens
Hoofdauteurs: Agarwal, Jasmin R., Wang, Qiuju, Tanno, Toshihiko, Rasheed, Zeshaan, Merchant, Akil, Ghosh, Nilanjan, Borrello, Ivan, Huff, Carol Ann, Parhami, Farhad, Matsui, William
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4182725/
https://ncbi.nlm.nih.gov/pubmed/24807964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0997
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