The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma

Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of pancreatic ductal adenocarcinoma (PDAC). A hallmark of PDAC is the desmoplastic reaction, but the impact of the tumor microenvironment (TME) on CSCs is unknown. In order to better understand the mechanisms, we...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Begum, Asma, Ewachiw, Theodore, Jung, Clinton, Huang, Ally, Norberg, K. Jessica, Marchionni, Luigi, McMillan, Ross, Penchev, Vesselin, Rajeshkumar, N. V., Maitra, Anirban, Wood, Laura, Wang, Chenguang, Wolfgang, Christopher, DeJesus-Acosta, Ana, Laheru, Daniel, Shapiro, Irina M., Padval, Mahesh, Pachter, Jonathan A., Weaver, David T., Rasheed, Zeshaan A., Matsui, William
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503247/
https://ncbi.nlm.nih.gov/pubmed/28692661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180181
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