Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters

We have repurposed (N)-methanocarba adenosine derivatives (A(3) adenosine receptor (AR) agonists) to enhance radioligand binding allosterically at the human dopamine (DA) transporter (DAT) and inhibit DA uptake. We extended the structure-activity relationship of this series with small N(6)-alkyl sub...

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Vydáno v:J Med Chem
Hlavní autoři: Tosh, Dilip K., Janowsky, Aaron, Eshleman, Amy J., Warnick, Eugene, Gao, Zhan-Guo, Chen, Zhoumou, Gizewski, Elizabeth, Auchampach, John A., Salvemini, Daniela, Jacobson, Kenneth A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501184/
https://ncbi.nlm.nih.gov/pubmed/28319392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00141
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