AML-induced osteogenic differentiation in mesenchymal stromal cells supports leukemia growth

Genotypic and phenotypic alterations in the bone marrow (BM) microenvironment, in particular in osteoprogenitor cells, have been shown to support leukemogenesis. However, it is unclear how leukemia cells alter the BM microenvironment to create a hospitable niche. Here, we report that acute myeloid l...

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Publicado en:JCI Insight
Main Authors: Battula, V. Lokesh, Le, Phuong M., Sun, Jeffrey C., Nguyen, Khoa, Yuan, Bin, Zhou, Ximin, Sonnylal, Sonali, McQueen, Teresa, Ruvolo, Vivian, Michel, Keith A., Ling, Xiaoyang, Jacamo, Rodrigo, Shpall, Elizabeth, Wang, Zhiqiang, Rao, Arvind, Al-Atrash, Gheath, Konopleva, Marina, Davis, R. Eric, Harrington, Melvyn A., Cahill, Catherine W., Bueso-Ramos, Carlos, Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499365/
https://ncbi.nlm.nih.gov/pubmed/28679949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90036
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