Bone marrow stromal cells induce an ALDH(+) stem cell-like phenotype and enhance therapy resistance in AML through a TGF-β-p38-ALDH2 pathway

The bone marrow microenvironment (BME) in acute myeloid leukemia (AML) consists of various cell types that support the growth of AML cells and protect them from chemotherapy. Mesenchymal stromal cells (MSCs) in the BME have been shown to contribute immensely to leukemogenesis and chemotherapy resist...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yuan, Bin, El Dana, Fouad, Ly, Stanley, Yan, Yuanqing, Ruvolo, Vivian, Shpall, Elizabeth J., Konopleva, Marina, Andreeff, Michael, Battula, Venkata Lokesh
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703975/
https://ncbi.nlm.nih.gov/pubmed/33253299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0242809
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados