CXCR4 Inhibition Enhances Efficacy of FLT3 Inhibitors in FLT3-Mutated AML Augmented by Suppressed TGF-β Signaling

Given the proven importance of the CXCL12/CXCR4 axis in the stroma–acute myeloid leukemia (AML) interactions and the rapid emergence of resistance to FLT3 inhibitors, we investigated the efficacy and safety of a novel CXCR4 inhibitor, LY2510924, in combination with FLT3 inhibitors in preclinical mod...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Kim, Bo-Reum, Jung, Seung-Hyun, Han, A-Reum, Park, Gyeongsin, Kim, Hee-Je, Yuan, Bin, Battula, Venkata Lokesh, Andreeff, Michael, Konopleva, Marina, Chung, Yeun-Jun, Cho, Byung-Sik
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7407511/
https://ncbi.nlm.nih.gov/pubmed/32629802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12071737
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