Bone marrow stromal cells induce an ALDH(+) stem cell-like phenotype and enhance therapy resistance in AML through a TGF-β-p38-ALDH2 pathway

The bone marrow microenvironment (BME) in acute myeloid leukemia (AML) consists of various cell types that support the growth of AML cells and protect them from chemotherapy. Mesenchymal stromal cells (MSCs) in the BME have been shown to contribute immensely to leukemogenesis and chemotherapy resist...

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Publicat a:PLoS One
Autors principals: Yuan, Bin, El Dana, Fouad, Ly, Stanley, Yan, Yuanqing, Ruvolo, Vivian, Shpall, Elizabeth J., Konopleva, Marina, Andreeff, Michael, Battula, Venkata Lokesh
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703975/
https://ncbi.nlm.nih.gov/pubmed/33253299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0242809
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