AML-induced osteogenic differentiation in mesenchymal stromal cells supports leukemia growth

Genotypic and phenotypic alterations in the bone marrow (BM) microenvironment, in particular in osteoprogenitor cells, have been shown to support leukemogenesis. However, it is unclear how leukemia cells alter the BM microenvironment to create a hospitable niche. Here, we report that acute myeloid l...

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Publicat a:JCI Insight
Autors principals: Battula, V. Lokesh, Le, Phuong M., Sun, Jeffrey C., Nguyen, Khoa, Yuan, Bin, Zhou, Ximin, Sonnylal, Sonali, McQueen, Teresa, Ruvolo, Vivian, Michel, Keith A., Ling, Xiaoyang, Jacamo, Rodrigo, Shpall, Elizabeth, Wang, Zhiqiang, Rao, Arvind, Al-Atrash, Gheath, Konopleva, Marina, Davis, R. Eric, Harrington, Melvyn A., Cahill, Catherine W., Bueso-Ramos, Carlos, Andreeff, Michael
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499365/
https://ncbi.nlm.nih.gov/pubmed/28679949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90036
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