Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation

Delivery technologies are required for realizing the clinical potential of molecular medicines. This work presents an alternative technology to preformulated delivery systems by harnessing the natural transport properties of serum albumin using endogenous binding of gapmer antisense oligonucleotides...

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Bibliografiska uppgifter
I publikationen:Mol Ther
Huvudupphovsmän: Hvam, Michael Lykke, Cai, Yunpeng, Dagnæs-Hansen, Frederik, Nielsen, Jesper Sejrup, Wengel, Jesper, Kjems, Jørgen, Howard, Kenneth A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Gene & Cell Therapy 2017
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498835/
https://ncbi.nlm.nih.gov/pubmed/28641935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.05.009
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