Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation

Delivery technologies are required for realizing the clinical potential of molecular medicines. This work presents an alternative technology to preformulated delivery systems by harnessing the natural transport properties of serum albumin using endogenous binding of gapmer antisense oligonucleotides...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Hvam, Michael Lykke, Cai, Yunpeng, Dagnæs-Hansen, Frederik, Nielsen, Jesper Sejrup, Wengel, Jesper, Kjems, Jørgen, Howard, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498835/
https://ncbi.nlm.nih.gov/pubmed/28641935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.05.009
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