Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites

BACKGROUND: A primary concern when targeting HIV-1 RNA by means of antisense related technologies is the accessibility of the targets. Using a library selection approach to define the most accessible sites for 20-mer oligonucleotides annealing within the highly structured 5'-UTR of the HIV-1 ge...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jakobsen, Martin R, Haasnoot, Joost, Wengel, Jesper, Berkhout, Ben, Kjems, Jørgen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2007
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866241/
https://ncbi.nlm.nih.gov/pubmed/17459171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-29
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