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Fluorescent base analogues in gapmers enable stealth labeling of antisense oligonucleotide therapeutics
To expand the antisense oligonucleotide (ASO) fluorescence labeling toolbox beyond covalent conjugation of external dyes (e.g. ATTO-, Alexa Fluor-, or cyanine dyes), we herein explore fluorescent base analogues (FBAs) as a novel approach to endow fluorescent properties to ASOs. Both cytosine and ade...
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| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8166847/ https://ncbi.nlm.nih.gov/pubmed/34059711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-90629-1 |
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