Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation

Delivery technologies are required for realizing the clinical potential of molecular medicines. This work presents an alternative technology to preformulated delivery systems by harnessing the natural transport properties of serum albumin using endogenous binding of gapmer antisense oligonucleotides...

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Publicado en:Mol Ther
Autores principales: Hvam, Michael Lykke, Cai, Yunpeng, Dagnæs-Hansen, Frederik, Nielsen, Jesper Sejrup, Wengel, Jesper, Kjems, Jørgen, Howard, Kenneth A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498835/
https://ncbi.nlm.nih.gov/pubmed/28641935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.05.009
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