Unwinding of the C-terminal Residues of Neuropeptide Y is critical for Y2 Receptor Binding and Activation

Despite recent breakthroughs in G protein-coupled receptor (GPCR) structure characterization, there is only sparse data on how GPCRs recognize larger peptide ligands. Here, we integrate nuclear magnetic resonance (NMR) spectroscopy, molecular modeling, and double-cycle mutagenesis studies to obtain...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Main Authors: Kaiser, Anette, Müller, Paul, Zellmann, Tristan, Scheidt, Holger A., Thomas, Lars, Bosse, Mathias, Meier, Rene, Meiler, Jens, Huster, Daniel, Beck-Sickinger, Annette G., Schmidt, Peter
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497120/
https://ncbi.nlm.nih.gov/pubmed/25924821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411688
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