Unwinding of the C-terminal Residues of Neuropeptide Y is critical for Y2 Receptor Binding and Activation

Despite recent breakthroughs in G protein-coupled receptor (GPCR) structure characterization, there is only sparse data on how GPCRs recognize larger peptide ligands. Here, we integrate nuclear magnetic resonance (NMR) spectroscopy, molecular modeling, and double-cycle mutagenesis studies to obtain...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Angew Chem Int Ed Engl
Päätekijät: Kaiser, Anette, Müller, Paul, Zellmann, Tristan, Scheidt, Holger A., Thomas, Lars, Bosse, Mathias, Meier, Rene, Meiler, Jens, Huster, Daniel, Beck-Sickinger, Annette G., Schmidt, Peter
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497120/
https://ncbi.nlm.nih.gov/pubmed/25924821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411688
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia